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Reviewed, UniProtKB/Swiss-Prot Q9Y6F7 (CDY2_HUMAN)

Last modified November 3, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Testis-specific chromodomain protein Y 2
    EC=2.3.1.48
Gene names
Name: CDY2A
Synonyms: CDY2
AND
Name: CDY2B
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May have histone acetyltransferase activity By similarity.

Catalytic activity

Acetyl-CoA + histone = CoA + acetylhistone.

Subcellular location

Nucleus By similarity.

Tissue specificity

Testis specific.

Sequence similarities

Contains 1 chromo domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 541541Testis-specific chromodomain protein Y 2
PRO_0000080220

Regions

Domain6 – 6661Chromo

Secondary structure

1 ......................................... 541
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q9Y6F7-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 53F31A6603829E85

FASTA54160,524
        10         20         30         40         50         60 
MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE 

        70         80         90        100        110        120 
KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNCK LFAASKNVRR 

       130        140        150        160        170        180 
KAASTLSDTK NMEIINSTIE TLAPDSPFDH KKTVSGFQKL EKLDPIAADQ QDTVVFKVTE 

       190        200        210        220        230        240 
GKLLRDPLSH PGAEQTGIQN KTQMHPLMSQ MSGSVTASMA TGSATRKGIV VLIDPLAANG 

       250        260        270        280        290        300 
TTDMHTSVPR VKGGQRNITD DSRGQPFIKK MHFTIRLTES AITYRDIVVK KEDGFTQIVL 

       310        320        330        340        350        360 
STRSTEKNAL NTEVIKEMVN ALNSAAADDS KLVLFSAAGS VFCCGLDFGY FVRHLRNDRN 

       370        380        390        400        410        420 
TASLEMVDTI KNFVNTFIQF KKPIVVSVNG PAIGLGASIL PLCDLVWANE KAWFQTPYTT 

       430        440        450        460        470        480 
FGQSPDGCSS ITFPKMMGKA SANEMLIAGR KLTAREACAK GLVSQVFLTG TFTQEVMIQI 

       490        500        510        520        530        540 
KELASYNAIV LEECKALVRC NIKLELEQAN ERECEVLRKI WSSAQGIESM LKYVENKIDE 


F

« Hide

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References

« Hide 'large scale' references
[1]"Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."
Lahn B.T., Page D.C.
Nat. Genet. 21:429-433(1999) [PubMed: 10192397] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The crystal structure of catalytic domain of human testis-specific chromodomain protein Y."
Structural genomics consortium (SGC)
Submitted (FEB-2006) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 282-541.

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Cross-references

Sequence databases

AF080598 mRNA. Translation: AAD22733.1.
AK292233 mRNA. Translation: BAF84922.1.
BC069087 mRNA. Translation: AAH69087.1.
IPIIPI00181285.
RefSeqNP_001001722.1.
NP_004816.1.
UniGeneHs.251375
Hs.532657

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2FW2X-ray2.20A/B/C/D/E/F282-541[»]
SMRQ9Y6F7. Positions 1-64.
ModBaseSearch...

PTM databases

PhosphoSiteQ9Y6F7.

Proteomic databases

PRIDEQ9Y6F7.

Genome annotation databases

EnsemblENST00000250838; ENSP00000250838; ENSG00000182415; Homo sapiens. [Genome view]
ENST00000382867; ENSP00000372319; ENSG00000129873; Homo sapiens. [Genome view]
ENST00000426790; ENSP00000402280; ENSG00000182415; Homo sapiens. [Genome view]
GeneID203611.
9426.
KEGGhsa:203611.
hsa:9426.
UCSCuc004ftl.1. human.

Organism-specific databases

CTD203611.
9426.
GeneCardsGC0YM018499.
GC0YP018648.
H-InvDBHIX0056665.
HIX0056697.
HGNCHGNC:1810. CDY2A.
HGNC:23921. CDY2B.
MIM400018. gene.
PharmGKBPA26355.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9Y6F7.
HOVERGENQ9Y6F7.
OMAMLKYVEN.

Enzyme and pathway databases

BRENDA2.3.1.48. 247.

Gene expression databases

CleanExHS_CDY2A.
HS_CDY2B.
GenevestigatorQ9Y6F7.
GermOnlineENSG00000129873. Homo sapiens.
ENSG00000182415. Homo sapiens.

Family and domain databases

InterProIPR017984. Chromo_dom_subgr.
IPR000953. Chromodomain.
IPR001753. Crotonase_core.
[Graphical view]
PfamPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
PRINTSPR00504. CHROMODOMAIN.
SMARTSM00298. CHROMO. 1 hit.
[Graphical view]
PROSITEPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio90458.
SOURCESearch...

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Entry information

Entry nameCDY2_HUMAN
AccessionPrimary (citable) accession number: Q9Y6F7
Secondary accession number(s): A8K868
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: November 3, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents