Reviewed, UniProtKB/Swiss-Prot Q9BVV7 (TI21L_HUMAN)

Names and origin

Protein names

Recommended name:
    TIM21-like protein, mitochondrial

Gene names

Name:	C18orf55
ORF Names:	HSPC154

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane By similarity.
Subcellular location	Mitochondrion membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the TIM21 family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Membrane Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 18	18	Mitochondrion Potential
	Chain	19 – 248	230	TIM21-like protein, mitochondrial		PRO_0000043228
Regions
	Transmembrane	108 – 128	21	Potential
Natural variations
	Natural variant	79	1	G → S: dbSNP rs3737512.		VAR_052306
Experimental info
	Sequence conflict	34	1	C → Y in AAF29118. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BVV7-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7BA2694A9DCD9024	FASTA	248	28,202
	10 20 30 40 50 60 MICTFLRAVQ YTEKLHRSSA KRLLLPYIVL NKACLKTEPS LRCGLQYQKK TLRPRCILGV 70 80 90 100 110 120 TQKTIWTQGP SPRKAKEDGS KQVSVHRSQR GGTAVPTSQK VKEAGRDFTY LIVVLFGISI 130 140 150 160 170 180 TGGLFYTIFK ELFSSSSPSK IYGRALEKCR SHPEVIGVFG ESVKGYGEVT RRGRRQHVRF 190 200 210 220 230 240 TEYVKDGLKH TCVKFYIEGS EPGKQGTVYA QVKENPGSGE YDFRYIFVEI ESYPRRTIII EDNRSQDD

References

[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix carcinoma.
[3]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF161503 mRNA. Translation: AAF29118.1. BC000892 mRNA. Translation: AAH00892.1.
IPI	IPI00306439.
RefSeq	NP_054896.2.
UniGene	Hs.532835
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9BVV7.
Proteomic databases
PRIDE	Q9BVV7.
Genome annotation databases
Ensembl	ENST00000169551; ENSP00000169551; ENSG00000075336; Homo sapiens. [Genome view]
GeneID	29090.
KEGG	hsa:29090.
UCSC	uc010dqr.1. human.
Organism-specific databases
CTD	29090.
GeneCards	GC18P069967.
HGNC	HGNC:25010. C18orf55.
HPA	HPA010587.
PharmGKB	PA134897360.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BVV7.
HOVERGEN	Q9BVV7.
OMA	MRVKFYI.
Gene expression databases
ArrayExpress	Q9BVV7.
Bgee	Q9BVV7.
CleanEx	HS_C18orf55.
Genevestigator	Q9BVV7.
GermOnline	ENSG00000075336. Homo sapiens.
Family and domain databases
InterPro	IPR013261. Tim21. [Graphical view]
Pfam	PF08294. TIM21. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	52098.

Entry information

Entry name

TI21L_HUMAN

Accession

Primary (citable) accession number: Q9BVV7
Secondary accession number(s): Q9P010

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.