Reviewed, UniProtKB/Swiss-Prot Q99541 (ADFP_HUMAN)

Names and origin

Protein names

Recommended name:
    Adipophilin
Alternative name(s):
    Adipose differentiation-related protein
      Short name=ADRP

Gene names

Name:

ADFP

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in development and maintenance of adipose tissue By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Tissue specificity	Milk lipid globules.
Post-translational modification	Acylated; primarily with C14, C16 and C18 fatty acids.
Sequence similarities	Belongs to the perilipin family.

Ontologies

Keywords
Cellular component	Membrane
PTM	Lipoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Ref.1 Traceable author statement. Source: ProtInc extracellular region Ref.1 Traceable author statement. Source: ProtInc extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell lipid particle Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Adipophilin		PRO_0000099888
Experimental info
	Sequence conflict	305 – 306	2	HI → QF in CAA65989. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q99541-1 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: 36411341619E53BF	FASTA	437	48,075
	10 20 30 40 50 60 MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA ENGVKTITSV 70 80 90 100 110 120 AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP STQIVANAKG AVTGAKDAVT 130 140 150 160 170 180 TTVTGAKDSV ASTITGVMDK TKGAVTGSVE KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL 190 200 210 220 230 240 TKSELLVEQY LPLTEEELEK EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK 250 260 270 280 290 300 EAKQKSQQTI SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES 310 320 330 340 350 360 HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA GDIYSVFRNA 370 380 390 400 410 420 ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQLT ESQNAQDQGA 430 EMDKSSQETQ RSEHKTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane." Heid H.W., Schnolzer M., Keenan T.W. Biochem. J. 320:1025-1030(1996) [PubMed: 9003395] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Tangkeangsirisin W., Serrero G. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X97324 mRNA. Translation: CAA65989.1. AF443203 mRNA. Translation: AAL35614.1. BC005127 mRNA. Translation: AAH05127.1.
IPI	IPI00293307.
RefSeq	NP_001113.2.
UniGene	Hs.3416
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99541. 1 interaction.
STRING	Q99541.
Proteomic databases
PeptideAtlas	Q99541.
PRIDE	Q99541.
Genome annotation databases
Ensembl	ENST00000276914; ENSP00000276914; ENSG00000147872; Homo sapiens. [Genome view] ENST00000380464; ENSP00000369831; ENSG00000147872; Homo sapiens. [Genome view] ENST00000380465; ENSP00000369832; ENSG00000147872; Homo sapiens. [Genome view] ENST00000411567; ENSP00000415270; ENSG00000147872; Homo sapiens. [Genome view] ENST00000434144; ENSP00000403421; ENSG00000147872; Homo sapiens. [Genome view]
GeneID	123.
KEGG	hsa:123.
UCSC	uc003zno.1. human.
Organism-specific databases
CTD	123.
GeneCards	GC09M019105.
H-InvDB	HIX0007945.
HGNC	HGNC:248. ADFP.
MIM	103195. gene.
PharmGKB	PA24569.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q99541.
HOVERGEN	Q99541.
OMA	YVSTKDQ.
Enzyme and pathway databases
Pathway_Interaction_DB	hif1_tfpathway. HIF-1-alpha transcription factor network.
Reactome	REACT_602. Metabolism of lipids and lipoproteins.
Gene expression databases
ArrayExpress	Q99541.
Bgee	Q99541.
CleanEx	HS_ADFP.
Genevestigator	Q99541.
GermOnline	ENSG00000147872. Homo sapiens.
Family and domain databases
InterPro	IPR004279. Perilipin. [Graphical view]
PANTHER	PTHR14024. Perilipin. 1 hit.
Pfam	PF03036. Perilipin. 1 hit. [Graphical view]
PIRSF	PIRSF036881. PAT. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	491.
SOURCE	Search...

Entry information

Entry name

ADFP_HUMAN

Accession

Primary (citable) accession number: Q99541
Secondary accession number(s): Q9BSC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 27, 2002
Last modified:	November 3, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.