Adenylate cyclase type 2 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q08462 (ADCY2_HUMAN)

Last modified November 3, 2009. Version 96. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Adenylate cyclase type 2
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type II
    ATP pyrophosphate-lyase 2
    Adenylyl cyclase 2

Gene names

Name:	ADCY2
Synonyms:	KIAA1060

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1091 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

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Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity by G-protein signaling pathway Inferred from Experiment. Source: Reactome activation of protein kinase A activity Inferred from Experiment. Source: Reactome cAMP biosynthetic process Non-traceable author statement. Source: UniProtKB hormone-mediated signaling pathway Inferred from Experiment. Source: Reactome inhibition of adenylate cyclase activity by G-protein signaling Inferred from Experiment. Source: Reactome
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Ref.4 Non-traceable author statement. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1091

1091

Adenylate cyclase type 2

PRO_0000195684

Regions

Topological domain

1 – 45

Cytoplasmic Potential

Transmembrane

46 – 66

Potential

Transmembrane

76 – 96

Potential

Transmembrane

108 – 128

Potential

Transmembrane

133 – 153

Potential

Transmembrane

159 – 179

Potential

Transmembrane

187 – 207

Potential

Topological domain

208 – 601

394

Cytoplasmic Potential

Transmembrane

602 – 622

Potential

Transmembrane

628 – 652

Potential

Transmembrane

680 – 701

Potential

Transmembrane

734 – 755

Potential

Transmembrane

763 – 780

Potential

Transmembrane

801 – 821

Potential

Topological domain

822 – 1091

270

Cytoplasmic Potential

Sites

Metal binding

295

Magnesium 1 By similarity

Metal binding

295

Magnesium 2 By similarity

Metal binding

296

Magnesium 2; via carbonyl oxygen By similarity

Metal binding

339

Magnesium 1 By similarity

Metal binding

339

Magnesium 2 By similarity

Amino acid modifications

Glycosylation

713

N-linked (GlcNAc...) Potential

Glycosylation

716

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

147

V → L: dbSNP rs13166360. Ref.2

VAR_029012

Natural variant

163

V → I: dbSNP rs34043481.

VAR_048247

Experimental info

Sequence conflict

188 – 207

VWQIL…LAGAY → GLADPGQCDHFHLWEPGXTN in AAP97285. Ref.1

Sequence conflict

675

R → Q in CAA52282. Ref.4

Sequence conflict

675

R → Q in AAA64923. Ref.4

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Sequences

Sequence

Length

Mass (Da)

Tools

Q08462-1 [UniParc].

Last modified November 28, 2006. Version 5.
Checksum: 41FD8BC607C075D1
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FASTA

1,091

123,603

        10         20         30         40         50         60 
MWQEAMRRRR YLRDRSEEAA GGGDGLPRSR DWLYESYYCM SQQHPLIVFL LLIVMGSCLA 

        70         80         90        100        110        120 
LLAVFFALGL EVEDHVAFLI TVPTALAIFF AIFILVCIES VFKKLLRLFS LVIWICLVAM 

       130        140        150        160        170        180 
GYLFMCFGGT VSPWDQVSFF LFIIFVVYTM LPFNMRDAII ASVLTSSSHT IVLSVCLSAT 

       190        200        210        220        230        240 
PGGKEHLVWQ ILANVIIFIC GNLAGAYHKH LMELALQQTY QDTCNCIKSR IKLEFEKRQQ 

       250        260        270        280        290        300 
ERLLLSLLPA HIAMEMKAEI IQRLQGPKAG QMENTNNFHN LYVKRHTNVS ILYADIVGFT 

       310        320        330        340        350        360 
RLASDCSPGE LVHMLNELFG KFDQIAKENE CMRIKILGDC YYCVSGLPIS LPNHAKNCVK 

       370        380        390        400        410        420 
MGLDMCEAIK KVRDATGVDI NMRVGVHSGN VLCGVIGLQK WQYDVWSHDV TLANHMEAGG 

       430        440        450        460        470        480 
VPGRVHISSV TLEHLNGAYK VEEGDGDIRD PYLKQHLVKT YFVINPKGER RSPQHLFRPR 

       490        500        510        520        530        540 
HTLDGAKMRA SVRMTRYLES WGAAKPFAHL HHRDSMTTEN GKISTTDVPM GQHNFQNRTL 

       550        560        570        580        590        600 
RTKSQKKRFE EELNERMIQA IDGINAQKQW LKSEDIQRIS LLFYNKVLEK EYRATALPAF 

       610        620        630        640        650        660 
KYYVTCACLI FFCIFIVQIL VLPKTSVLGI SFGAAFLLLA FILFVCFAGQ LLQCSKKASP 

       670        680        690        700        710        720 
LLMWLLKSSG IIANRPWPRI SLTIITTAII LMMAVFNMFF LSDSEETIPP TANTTNTSFS 

       730        740        750        760        770        780 
ASNNQVAILR AQNLFFLPYF IYSCILGLIS CSVFLRVNYE LKMLIMMVAL VGYNTILLHT 

       790        800        810        820        830        840 
HAHVLGDYSQ VLFERPGIWK DLKTMGSVSL SIFFITLLVL GRQNEYYCRL DFLWKNKFKK 

       850        860        870        880        890        900 
EREEIETMEN LNRVLLENVL PAHVAEHFLA RSLKNEELYH QSYDCVCVMF ASIPDFKEFY 

       910        920        930        940        950        960 
TESDVNKEGL ECLRLLNEII ADFDDLLSKP KFSGVEKIKT IGSTYMAATG LSAVPSQEHS 

       970        980        990       1000       1010       1020 
QEPERQYMHI GTMVEFAFAL VGKLDAINKH SFNDFKLRVG INHGPVIAGV IGAQKPQYDI 

      1030       1040       1050       1060       1070       1080 
WGNTVNVASR MDSTGVLDKI QVTEETSLVL QTLGYTCTCR GIINVKGKGD LKTYFVNTEM 

      1090 
SRSLSQSNVA S

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human adenylyl cyclase gene." Guo J.H., Yu L. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-147.
[3]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-1091. Tissue: Brain.
[4]	"Different chromosomal localization of two adenylyl cyclase genes expressed in human brain." Stengel D., Parma J., Gannage M.-H., Roeckel N., Mattei M.-G., Barouki R., Hanoune J. Hum. Genet. 90:126-130(1992) [PubMed: 1427768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 616-1091. Tissue: Brain.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AF410885 mRNA. Translation: AAP97285.1. BC111743 mRNA. Translation: AAI11744.1. AB028983 mRNA. Translation: BAA83012.1. X74210 mRNA. Translation: CAA52282.1. L21993 mRNA. Translation: AAA64923.1.
IPI	IPI00328273.
PIR	I37136.
RefSeq	NP_065433.2.
UniGene	Hs.481545
3D structure databases
HSSP	HSSP built from PDB template 1AB8 based on UniProtKB P26769.
SMR	Q08462. Positions 879-1078.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:422N.
STRING	Q08462.
PTM databases
PhosphoSite	Q08462.
Proteomic databases
PRIDE	Q08462.
Genome annotation databases
Ensembl	ENST00000338316; ENSP00000342952; ENSG00000078295; Homo sapiens. [Genome view] ENST00000382531; ENSP00000371971; ENSG00000078295; Homo sapiens. [Genome view] ENST00000382532; ENSP00000371972; ENSG00000078295; Homo sapiens. [Genome view]
GeneID	108.
KEGG	hsa:108.
UCSC	uc003jdz.1. human.
Organism-specific databases
CTD	108.
GeneCards	GC05P007449. GC05P007450.
HGNC	HGNC:233. ADCY2.
MIM	103071. gene.
PharmGKB	PA24561.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q08462.
OMA	FLPYFIY.
Enzyme and pathway databases
BRENDA	4.6.1.1. 247.
Pathway_Interaction_DB	endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. lpa4_pathway. LPA4-mediated signaling events.
Reactome	REACT_11061. Signalling by NGF. REACT_14797. Signaling by GPCR. REACT_1505. Integration of energy metabolism. REACT_15295. Opioid Signalling.
Gene expression databases
ArrayExpress	Q08462.
Bgee	Q08462.
CleanEx	HS_ADCY2.
Genevestigator	Q08462.
GermOnline	ENSG00000078295. Homo sapiens.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Aden_cycl-like. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	419.
SOURCE	Search...

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Entry information

Entry name

ADCY2_HUMAN

Accession

Primary (citable) accession number: Q08462
Secondary accession number(s): Q2NKL8, Q9UPU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	November 28, 2006
Last modified:	November 3, 2009
This is version 96 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents