Reviewed, UniProtKB/Swiss-Prot P56072 (SDHL_HELPY)

Names and origin

Protein names

Recommended name:
    L-serine dehydratase
      Short name=SDH
    EC=4.3.1.17
Alternative name(s):
    L-serine deaminase
      Short name=L-SD

Gene names

Name:	sdaA
Ordered Locus Names:	HP_0132

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Binds 1 4Fe-4S cluster Probable.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Sequence similarities	Belongs to the iron-sulfur dependent L-serine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	L-serine dehydratase		PRO_0000171907

Sequences

	Sequence		Length	Mass (Da)
	P56072-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 4F5B5067C1DB0DC7	FASTA	455	49,242
	10 20 30 40 50 60 MASFSILSIF KIGVGPSSSH TIGPMEAGAR FCESLKGILE QVVRVQITLH GSLALTGKGH 70 80 90 100 110 120 LSDEAVLIGL HGIYANELEV TTKKALLHEA LENKVLKLAN QHHIPFDYAK DLIFDNKPLT 130 140 150 160 170 180 RHQNALILKA FNSKNEVLKE ETYYSVGGGF VYTEKELDNL SEEDGNESIA YDFSSAKELL 190 200 210 220 230 240 ELCQKHQKSI AEIVRLRENA LKNHPDATMV KIYHAMLECY DNGANSKERY LPGSLKVTRL 250 260 270 280 290 300 APSIKTRLEK HPTSGKDPLA LIDYISLYAR AIAEENASGG KVVTAPTNGA CAVVPSVLLY 310 320 330 340 350 360 AKNHLFENLS QKAINDFLLT SAAIGYLYKK NASLSGAEAG CQAEIGVASS MAAGGLAHLC 370 380 390 400 410 420 QATTQQVLIA SEIAMEHHLG LTCDPVGGLV QIPCIERNVL GAIKAISASK LALEDEYKPK 430 440 450 VSLDEVIATM YATGKDMNEK YKETSLGGLA KTLKC

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07202.1.
PIR	D64536.
RefSeq	NP_206932.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3172N.
Genome annotation databases
GeneID	900301.
GenomeReviews	Gene locus HP_0132 in contig AE000511_GR.
KEGG	hpy:HP0132.
NMPDR	fig|85962.1.peg.130.
TIGR	HP_0132.
Phylogenomic databases
HOGENOM	P56072.
OMA	NELAFRS.
Enzyme and pathway databases
BRENDA	4.3.1.17. 1131.
Family and domain databases
InterPro	IPR004644. Fe-S_L-Ser_mono. IPR005130. Ser_deHydtase_asu. IPR005131. Ser_deHydtase_bsu. [Graphical view]
Pfam	PF03313. SDH_alpha. 1 hit. PF03315. SDH_beta. 1 hit. [Graphical view]
TIGRFAMs	TIGR00720. sda_mono. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SDHL_HELPY

Accession

Primary (citable) accession number: P56072

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)