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Reviewed, UniProtKB/Swiss-Prot P42403 (BGLC_BACSU)

Last modified November 3, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aryl-phospho-beta-D-glucosidase bglC
    EC=3.2.1.86
Alternative name(s):
    6-phospho-beta-glucosidase
Gene names
Name: bglC
Synonyms: yckE
Ordered Locus Names: BSU03410
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Is able to catalyze the hydrolysis of aryl-phospho-beta-D-glucosides such as 4-methylumbelliferyl-phospho-beta-D-glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Is not essential for growth on arbutin and salicin as the sole carbon source. Ref.5

Catalytic activity

6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate.

Developmental stage

Expressed at a low and constant level during growth, sporulation, and spore germination. Ref.5

Induction

Is not induced by aryl-beta-D-glucosides such as arbutin, salicin or 4-methylumbelliferyl-beta-D-glucopyranoside (MUG). Is not repressed by glucose. Ref.5

Sequence similarities

Belongs to the glycosyl hydrolase 1 family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function6-phospho-beta-glucosidase activity

Inferred from electronic annotation. Source: EC

cation binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477Aryl-phospho-beta-D-glucosidase bglC
PRO_0000063874

Sites

Active site1701Proton donor Potential
Active site3781Nucleophile By similarity

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Sequences

Sequence LengthMass (Da)Tools
P42403-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 64045E7E4C1A10E4

FASTA47755,140
        10         20         30         40         50         60 
MIHQHPESFP KHFLWGSASA AYQIEGAWNE DGKGPSVWDV FTKIPGKTFK GTNGEIAVDH 

        70         80         90        100        110        120 
YHRFKEDVAL MAEMGLKAYR FSVSWPRVFP KGKGEINEAG LAFYDSLIDE LLSHHIEPVL 

       130        140        150        160        170        180 
TLYHWDLPQA LMDEYGGFES RNIIEDFNHY CITLYKRFGD RVKYWVTLNE QNYNFNHGFI 

       190        200        210        220        230        240 
TAMHPPGVKD RKRFYEANHI AFLANAKAIE SFREYVPEGK IGPSFAYSPA YPLSSHPEDI 

       250        260        270        280        290        300 
LAFENAEEFT NNWWLDMYCW GTYPQIPFRC LEKQGWAPTI EAGDMDLLAK GKPDFVGVNY 

       310        320        330        340        350        360 
YQTITYERNP LDGVSEGKMN TTGQKGTNQE TGIPGVFKTK KNPHLTTSNW DWTIDPIGLR 

       370        380        390        400        410        420 
IGLRRITSRY QLPVFITENG LGEFDKVEDG TVQDDYRIDY LRSHLEQCRQ AISDGVDLIG 

       430        440        450        460        470 
YCSWSFTDLL SWLNGYQKRY GFVYVNRDEE STSDLKRLKK KSFYWYQDVI KTNGESL

« Hide

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References

« Hide 'large scale' references
[1]"A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of srfAA of the Bacillus subtilis chromosome."
Fujishima Y., Yamane K.
Microbiology 141:277-279(1995) [PubMed: 7704255] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
Yamane K., Kumano M., Kurita K.
Microbiology 142:3047-3056(1996) [PubMed: 8969502] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"Transformation in Bacillus subtilis: involvement of the 17-kilodalton DNA-entry nuclease and the competence-specific 18-kilodalton protein."
Vosman B., Kuiken G., Kooistra J., Venema G.
J. Bacteriol. 170:3703-3710(1988) [PubMed: 2841296] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 461-477.
[5]"Identification of aryl-phospho-beta-D-glucosidases in Bacillus subtilis."
Setlow B., Cabrera-Hernandez A., Cabrera-Martinez R.M., Setlow P.
Arch. Microbiol. 181:60-67(2004) [PubMed: 14652714] [Abstract]
Cited for: FUNCTION AS AN ARYL-PHOSPHO-BETA-D-GLUCOSIDASE, DEVELOPMENTAL STAGE, INDUCTION, GENE NAME.
Strain: 168 / PS832.

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Cross-references

Sequence databases

D30762 Genomic DNA. Translation: BAA06429.1.
D50453 Genomic DNA. Translation: BAA08975.1.
AL009126 Genomic DNA. Translation: CAB12135.1.
M21672 Genomic DNA. No translation available.
PIRG69760.
RefSeqNP_388223.1.

3D structure databases

HSSPHSSP built from PDB template 1PBG based on UniProtKB P11546.
ModBaseSearch...

Protein family/group databases

CAZyGH1. Glycoside Hydrolase Family 1.

Genome annotation databases

GeneID938317.
GenomeReviewsGene locus BSU03410 in contig AL009126_GR.
KEGGbsu:BSU03410.
NMPDRfig|224308.1.peg.342.

Organism-specific databases

SubtiListBG11181. bglC. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP42403.
OMAGPSVWDV.

Enzyme and pathway databases

BioCycBSUB224308:BSU0342-MON.
BRENDA3.2.1.21. 150.

Family and domain databases

InterProIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_sg_catalytic.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PANTHERPTHR10353. Glyco_hydro_1. 1 hit.
PfamPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSPR00131. GLHYDRLASE1.
PROSITEPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameBGLC_BACSU
AccessionPrimary (citable) accession number: P42403
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 3, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents