Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P37898 (AAP1_YEAST)

Last modified November 3, 2009. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Alanine/arginine aminopeptidase
    EC=3.4.11.-
Gene names
Name: AAP1
Ordered Locus Names: YHR047C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Hide | Top

Protein attributes

Sequence length856 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Positive effector of glycogen accumulation. May be involved in nutrient-sensing.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Miscellaneous

Present with 77000 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Belongs to the peptidase M1 family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 856856Alanine/arginine aminopeptidase
PRO_0000095105

Sites

Active site3011 By similarity
Active site3861Proton donor Potential
Metal binding3001Zinc; catalytic By similarity
Metal binding3041Zinc; catalytic By similarity
Metal binding3231Zinc; catalytic By similarity

Amino acid modifications

Modified residue2481Phosphotyrosine Ref.4

Experimental info

Sequence conflict550 – 56920Missing Ref.2
Sequence conflict6461V → E Ref.2

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P37898-1 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 0209F9E0298DF9DB

FASTA85697,663
        10         20         30         40         50         60 
MSREVLPNNV TPLHYDITLE PNFRAFTFEG SLKIDLQIND HSINSVQINY LEIDFHSARI 

        70         80         90        100        110        120 
EGVNAIEVNK NENQQKATLV FPNGTFENLG PSAKLEIIFS GILNDQMAGF YRAKYTDKVT 

       130        140        150        160        170        180 
GETKYMATTQ MEATDARRAF PCFDEPNLKA TFAVTLVSES FLTHLSNMDV RNETIKEGKK 

       190        200        210        220        230        240 
YTTFNTTPKM STYLVAFIVA DLRYVESNNF RIPVRVYSTP GDEKFGQFAA NLAARTLRFF 

       250        260        270        280        290        300 
EDTFNIEYPL PKMDMVAVHE FSAGAMENWG LVTYRVIDLL LDIENSSLDR IQRVAEVIQH 

       310        320        330        340        350        360 
ELAHQWFGNL VTMDWWEGLW LNEGFATWMS WYSCNKFQPE WKVWEQYVTD NLQRALNLDS 

       370        380        390        400        410        420 
LRSSHPIEVP VNNADEINQI FDAISYSKGS SLLRMISKWL GEETFIKGVS QYLNKFKYGN 

       430        440        450        460        470        480 
AKTGDLWDAL ADASGKDVCS VMNIWTKRVG FPVLSVKEHK NKITLTQHRY LSTGDVKEEE 

       490        500        510        520        530        540 
DTTIYPILLA LKDSTGIDNT LVLNEKSATF ELKNEEFFKI NGDQSGIFIT SYSDERWAKL 

       550        560        570        580        590        600 
SKQANLLSVE DRVGLVADAK ALSASGYTST TNFLNLISNW KNEDSFVVWE QIINSLSALK 

       610        620        630        640        650        660 
STWVFEPEDI LNALDKFTLD LVLNKLSELG WNIGEDDSFA IQRLKVTLFS AACTSGNEKM 

       670        680        690        700        710        720 
QSIAVEMFEE YANGNKQAIP ALFKAVVFNT VARLGGENNY EKIFNIYQNP VSSEEKIIAL 

       730        740        750        760        770        780 
RALGRFEDKE LLERTLSYLL DGTVLNQDFY IPMQGIRVHK KGIERLWAWM QEHWDEIAKR 

       790        800        810        820        830        840 
LQPGSPVLGG VLTLGLTNFT SFEALEKISA FYSRKVTKGF DQTLAQALDT IRSKAQWVSR 

       850 
DREIVATYLR EHEYDQ

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast."
Caprioglio D.R., Padilla C., Werner-Washburne M.
J. Biol. Chem. 268:14310-14315(1993) [PubMed: 8100228] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 107-652.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-248, MASS SPECTROMETRY.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

L12542 Genomic DNA. No translation available.
U00062 Genomic DNA. Translation: AAB68919.1.
PIRS46750.
RefSeqNP_011913.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6698N.
STRINGP37898.

Proteomic databases

PeptideAtlasP37898.

Genome annotation databases

EnsemblYHR047C; YHR047C; YHR047C; Saccharomyces cerevisiae. [Genome view]
GeneID856443.
GenomeReviewsGene locus YHR047C in contig U00093_GR.
KEGGsce:YHR047C.
NMPDRfig|4932.3.peg.3062.

Organism-specific databases

CYGDYHR047c.
SGDS000001089. AAP1'.

Phylogenomic databases

HOGENOMP37898.
OMAIRISARW.

Gene expression databases

ArrayExpressP37898.
GenevestigatorP37898.
GermOnlineYHR047C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR006025. Pept_M_Zn_BS.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERPTHR11533. Peptidase_M1. 1 hit.
PfamPF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSPR00756. ALADIPTASE.
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio982057.

Hide | Top

Entry information

Entry nameAAP1_YEAST
AccessionPrimary (citable) accession number: P37898
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1995
Last modified: November 3, 2009
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Hide | Top

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents