Reviewed, UniProtKB/Swiss-Prot P34725 (AROF_CANAL)

Names and origin

Protein names

Recommended name:
    Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited
    EC=2.5.1.54
Alternative name(s):
    Phospho-2-keto-3-deoxyheptonate aldolase
    3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
    DAHP synthetase

Gene names

Name:

ARO3

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Enzyme regulation	Inhibited by phenyalanine.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Sequence similarities	Belongs to the class-I DAHP synthetase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Transferase
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited		PRO_0000140848

Sequences

	Sequence		Length	Mass (Da)
	P34725-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 3F5F64E1A6A80F73	FASTA	368	40,731
	10 20 30 40 50 60 MFITNEHVGD RSRMEDWRIR GYDPLTPPDL LQHEYPLTPE SQKIIVEGRN AACDILNGKD 70 80 90 100 110 120 RRLIGPCSIH DPQAALDYCE RLYQASEKHK GELLIVMRAY LEKPRTTVGW KGLINDPDID 130 140 150 160 170 180 GTFHINKGLR IARKLFVQLT SKLPIAGEML DTISPQFLSD LFSVGAIGAR TTESQLHREL 190 200 210 220 230 240 ASGYHSQLDS KTVPMVLWVL PLTPLRAASH PHHFLSVTKP GVVAIVGTDG NQDCFVILRG 250 260 270 280 290 300 GKKGTNYDAK SVQETQEELI KSKVVTEMKP GPRIMVDCSH GNSNKDHRNQ PKVAQVVAEQ 310 320 330 340 350 360 VAGGDKSICG LMIESNINDG RQDVPPKEQG GKDALKYGVS ITDACIGWET TEEVLEVLAN AVKTRRSL

References

[1]	"Cloning and expression of the ARO3 gene encoding DAHP synthase from Candida albicans." Pereira S.A., Livi G.P. Gene 132:159-165(1993) [PubMed: 7901125] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 11651 / B792 / 171D.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L12217 Unassigned DNA. Translation: AAA71966.1.
PIR	JN0865.
3D structure databases
HSSP	HSSP built from PDB template 1HFB based on UniProtKB P32449.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.54. 1124.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. aroFGH. 2 hits.
ProtoNet	Search...

Entry information

Entry name

AROF_CANAL

Accession

Primary (citable) accession number: P34725

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	September 22, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)