Reviewed, UniProtKB/Swiss-Prot P33075 (KAD1_SCHPO)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	adk1
ORF Names:	SPAC4G9.03

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ADP biosynthetic process Ref.1 Inferred from genetic interaction. Source: GeneDB_SPombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Ref.1 Inferred from genetic interaction. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Adenylate kinase 1		PRO_0000158906
Regions
	Nucleotide binding	10 – 18	9	ATP By similarity
	Nucleotide binding	33 – 62	30	AMP By similarity
Sites
	Binding site	34	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P33075-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: F5335A025C971D78	FASTA	220	24,375
	10 20 30 40 50 60 MAGMRLILVG PPGAGKGTQA PNIQKKYGIA HLATGDMLRS QVARQTELGK EAKKIMDQGG 70 80 90 100 110 120 LVSDDIVTGM IKDEILNNPE CKNGFILDGF PRTVVQAEKL TALLDELKLD LNTVLELQVD 130 140 150 160 170 180 DELLVRRITG RLVHPGSGRS YHLEFNPPKV PMKDDVTGEP LIQRSDDNAD ALRKRLVTYH 190 200 210 220 EQTTPVVEFY KKKGKWAAVD AAQKPEQVWE QIVAILEKAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of the essential gene for adenylate kinase from the fission yeast Schizosaccharomyces pombe." Konrad M. J. Biol. Chem. 268:11326-11334(1993) [PubMed: 8496185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X70363 Genomic DNA. Translation: CAA49826.1. CU329670 Genomic DNA. Translation: CAA93553.1.
PIR	S31338. A46718.
RefSeq	NP_593685.1.
3D structure databases
HSSP	HSSP built from PDB template 1AKY based on UniProtKB P07170.
ModBase	Search...
Protein-protein interaction databases
STRING	P33075.
Genome annotation databases
GeneID	2542704.
GenomeReviews	Gene locus adk1 in contig CU329670_GR.
KEGG	spo:SPAC4G9.03.
NMPDR	fig|4896.1.peg.3655.
Organism-specific databases
GeneDB_Spombe	SPAC4G9.03.
Phylogenomic databases
OMA	KQTEPIV.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-001351-MON.
BRENDA	2.7.4.3. 653.
Gene expression databases
ArrayExpress	P33075.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_SCHPO

Accession

Primary (citable) accession number: P33075

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	November 3, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)