Reviewed, UniProtKB/Swiss-Prot P15567 (PUR6_SCHPO)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	ade6
Synonyms:	min1
ORF Names:	SPCC1322.13

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Sequence similarities	In the C-terminal section; belongs to the AIR carboxylase family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazole carboxylase activity Ref.1 Traceable author statement. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Phosphoribosylaminoimidazole carboxylase		PRO_0000075027
Regions
	Domain	108 – 295	188	ATP-grasp
	Nucleotide binding	134 – 189	56	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P15567-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 2C10AF7C4349808F	FASTA	552	60,013
	10 20 30 40 50 60 MSEKQVVGIL GGGQLGRMMV EAAHRLNIKC IILDAANSPA KQIDGGREHI DASFTDPDAI 70 80 90 100 110 120 VELSKKCTLL TTEIEHINTD ALAAVTKSVA VEPSPATLRC IQDKYLQKQH LQVFKIALPE 130 140 150 160 170 180 FCDAPDQESV EKAGQEFGYP FVLKSKTLAY DGRGNYVVHQ PSEIPTAIKA LGDRPLYVEK 190 200 210 220 230 240 FVPFSMEIAV MVVRSLDGKV YAYPTTETIQ KDNVCHLVYA PARLPFSIQQ RAQTLAMDAV 250 260 270 280 290 300 RTFEGAGIYG VEMFVLQDGE TILLNEIAPR PHNSGHYTIE ACPTSQFEAH LRAICGLPFS 310 320 330 340 350 360 EINTQLSTST THALMVNILG TDDPDYVSKI AKRSLSIPGA TLHLYGKAES RKGRKMGHVT 370 380 390 400 410 420 IISDSPQECE RRYQMLLDVK DPVESPVVGI IMGSDSDLSK MKDAAVILDE FKVPYELTIV 430 440 450 460 470 480 SAHRTPDRMV TYARTAASRG LRVIIAGAGG AAHLPGMVAA MTPLPVIGVP VKGSTLDGVD 490 500 510 520 530 540 SLHSIVQMPR GVPVATVAIN NSQNAGILAC RILATFQPSL LAAMESFMDN MKEIVLEKAD 550 KLEKVGWKNY SA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe. Wild-type and mutant alleles including the recombination host spot allele ade6-M26." Szankasi P., Heyer W.-D., Schuchert P., Kohli J. J. Mol. Biol. 204:917-925(1988) [PubMed: 3221399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M37264 Genomic DNA. Translation: AAA35285.1. X14488 Genomic DNA. Translation: CAA32650.1. CU329672 Genomic DNA. Translation: CAA22866.1.
PIR	DEZPP. S02159.
RefSeq	NP_588141.1.
3D structure databases
HSSP	HSSP built from PDB template 1O4V based on UniProtKB Q9WYS7.
ModBase	Search...
Protein-protein interaction databases
STRING	P15567.
Genome annotation databases
GeneID	2538734.
GenomeReviews	Gene locus ade6 in contig CU329672_GR.
KEGG	spo:SPCC1322.13.
NMPDR	fig|4896.1.peg.479.
Organism-specific databases
GeneDB_Spombe	SPCC1322.13.
Phylogenomic databases
OMA	RKIGHVN.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000083-MON.
BRENDA	4.1.1.21. 653.
Gene expression databases
ArrayExpress	P15567.
Family and domain databases
InterPro	IPR016301. AIR_COase. IPR005875. AIR_COase_ATPase-su. IPR000031. AIR_COase_core. IPR011761. ATP-grasp. IPR003135. ATP-grasp_carboxylate-amine. IPR013816. ATP_grasp_subdomain_2. IPR013817. Pre-ATP_grasp. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PANTHER	PTHR23047:SF1. PurK_ATP. 1 hit.
Pfam	PF00731. AIRC. 1 hit. PF02222. ATP-grasp. 1 hit. [Graphical view]
PIRSF	PIRSF001340. AIR_carboxylase. 1 hit.
ProDom	PD002193. AIR_carboxyl. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 1 hit. TIGR01161. purK. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR6_SCHPO

Accession

Primary (citable) accession number: P15567

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	November 3, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)