Reviewed, UniProtKB/Swiss-Prot P08183 (MDR1_HUMAN)

Names and origin

Protein names

Recommended name:
    Multidrug resistance protein 1
    EC=3.6.3.44
Alternative name(s):
    ATP-binding cassette sub-family B member 1
    P-glycoprotein 1
    CD_antigen=CD243

Gene names

Name:	ABCB1
Synonyms:	MDR1, PGY1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Catalytic activity	ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in liver, kidney, small intestine and brain.
Polymorphism	Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.
Involvement in disease	Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases. Ref.18
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.
Sequence caution	The sequence AAB69423.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to drug Traceable author statement. Source: ProtInc transport Traceable author statement. Source: ProtInc
Cellular component	cell surface Inferred from direct assay. Source: UniProtKB focal adhesion Inferred from direct assay. Source: HPA integral to membrane Traceable author statement. Source: ProtInc membrane fraction Traceable author statement. Source: ProtInc nucleus Inferred from direct assay. Source: HPA
Molecular function	ATP binding Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct xenobiotic-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RNF2	Q99496	1	EBI-1057359,EBI-722416

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1280	1280	Multidrug resistance protein 1		PRO_0000093332
Regions
	Topological domain	1 – 51	51	Cytoplasmic Potential
	Transmembrane	52 – 72	21	Potential
	Transmembrane	120 – 140	21	Potential
	Transmembrane	189 – 209	21	Potential
	Transmembrane	216 – 236	21	Potential
	Transmembrane	297 – 317	21	Potential
	Transmembrane	326 – 346	21	Potential
	Topological domain	347 – 710	364	Cytoplasmic Potential
	Transmembrane	711 – 731	21	Potential
	Transmembrane	757 – 777	21	Potential
	Transmembrane	833 – 853	21	Potential
	Transmembrane	854 – 874	21	Potential
	Transmembrane	937 – 957	21	Potential
	Transmembrane	974 – 994	21	Potential
	Topological domain	995 – 1280	286	Cytoplasmic Potential
	Domain	51 – 357	307	ABC transmembrane type-1 1
	Domain	392 – 628	237	ABC transporter 1
	Domain	711 – 1000	290	ABC transmembrane type-1 2
	Domain	1035 – 1273	239	ABC transporter 2
	Nucleotide binding	427 – 434	8	ATP 1 By similarity
	Nucleotide binding	1070 – 1077	8	ATP 2 By similarity
Amino acid modifications
	Modified residue	660	1	Phosphoserine By similarity
	Glycosylation	91	1	N-linked (GlcNAc...) Potential
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	17	1	F → L: dbSNP rs28381804. Ref.4		VAR_022276
	Natural variant	21	1	N → D: dbSNP rs9282564. Ref.4 Ref.5 Ref.12 Ref.13 Ref.14		VAR_014704
	Natural variant	44	1	N → S: dbSNP rs1202183.		VAR_055423
	Natural variant	80	1	A → E: dbSNP rs9282565.		VAR_055424
	Natural variant	103	1	F → L Rare polymorphism. Ref.13		VAR_015001
	Natural variant	108	1	E → K		VAR_018351
	Natural variant	185	1	G → V in a colchicine-selected multidrug-resistant cell line; confers increased resistance to colchicine. dbSNP rs1128501. Ref.1 Ref.3 Ref.10		VAR_015002
	Natural variant	261	1	I → V: dbSNP rs36008564.		VAR_055425
	Natural variant	400	1	S → N: dbSNP rs2229109. Ref.4 Ref.13 Ref.14		VAR_015003
	Natural variant	566	1	E → K: dbSNP rs28381902. Ref.4		VAR_022277
	Natural variant	593	1	R → C: dbSNP rs28381914. Ref.4		VAR_022278
	Natural variant	599	1	A → T: dbSNP rs2235036.		VAR_055426
	Natural variant	669	1	R → C: dbSNP rs35023033.		VAR_055427
	Natural variant	801	1	V → M: dbSNP rs2235039.		VAR_055428
	Natural variant	829	1	I → V: dbSNP rs2032581.		VAR_055429
	Natural variant	836	1	I → V: dbSNP rs28381967. Ref.4		VAR_022279
	Natural variant	887	1	K → N in a colorectal cancer sample; somatic mutation. Ref.20		VAR_035737
	Natural variant	893	1	S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. dbSNP rs2032582. Ref.18 Ref.4 Ref.14 Ref.1 Ref.3 Ref.2 Ref.11 Ref.17		VAR_013361
	Natural variant	893	1	S → T Rare allele. dbSNP rs2032582. Ref.18 Ref.14 Ref.17		VAR_013362
	Natural variant	986	1	M → V		VAR_018352
	Natural variant	999	1	A → T		VAR_015004
	Natural variant	1051	1	P → A: dbSNP rs28401798. Ref.4		VAR_022280
	Natural variant	1107	1	Q → P: dbSNP rs55852620. Ref.14		VAR_015005
	Natural variant	1141	1	S → T: dbSNP rs2229107. Ref.4		VAR_022281
	Natural variant	1251	1	V → I		VAR_018353
Experimental info
	Sequence conflict	23	1	S → R in CAA41558. Ref.8
	Sequence conflict	336	1	Missing in AAB69423. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P08183-1 [UniParc]. Last modified May 26, 2009. Version 3. Checksum: F0230744AB288C73	FASTA	1,280	141,479
	10 20 30 40 50 60 MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII 70 80 90 100 110 120 HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG 130 140 150 160 170 180 IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS 190 200 210 220 230 240 KINEGIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT 250 260 270 280 290 300 DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 310 320 330 340 350 360 AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP SIEAFANARG 370 380 390 400 410 420 AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS YPSRKEVKIL KGLNLKVQSG 430 440 450 460 470 480 QTVALVGNSG CGKSTTVQLM QRLYDPTEGM VSVDGQDIRT INVRFLREII GVVSQEPVLF 490 500 510 520 530 540 ATTIAENIRY GRENVTMDEI EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA 550 560 570 580 590 600 IARALVRNPK ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG 610 620 630 640 650 660 FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA LEMSSNDSRS 670 680 690 700 710 720 SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI MKLNLTEWPY FVVGVFCAII 730 740 750 760 770 780 NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ NSNLFSLLFL ALGIISFITF FLQGFTFGKA 790 800 810 820 830 840 GEILTKRLRY MVFRSMLRQD VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI 850 860 870 880 890 900 ANLGTGIIIS FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA 910 920 930 940 950 960 IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY FSYAGCFRFG 970 980 990 1000 1010 1020 AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK AKISAAHIIM IIEKTPLIDS 1030 1040 1050 1060 1070 1080 YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI PVLQGLSLEV KKGQTLALVG SSGCGKSTVV 1090 1100 1110 1120 1130 1140 QLLERFYDPL AGKVLLDGKE IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV 1150 1160 1170 1180 1190 1200 SQEEIVRAAK EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD 1210 1220 1230 1240 1250 1260 EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR VKEHGTHQQL 1270 1280 LAQKGIYFSM VSVQAGTKRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells." Chen C.-J., Chin J.E., Ueda K., Clark D.P., Pastan I., Gottesman M.M., Roninson I.B. Cell 47:381-389(1986) [PubMed: 2876781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-185 AND ALA-893.
[2]	"Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins." Chen C.-J., Clark D.P., Ueda K., Pastan I., Gottesman M.M., Roninson I.B. J. Biol. Chem. 265:506-514(1990) [PubMed: 1967175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-893.
[3]	"Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins." Chen G., Duran G.E., Steger K.A., Lacayo N.J., Jaffrezou J.P., Dumontet C., Sikic B.I. J. Biol. Chem. 272:5974-5982(1997) [PubMed: 9038218] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-185 AND ALA-893.
[4]	NIEHS SNPs program Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-17; ASP-21; ASN-400; LYS-566; CYS-593; VAL-836; ALA-893; ALA-1051; THR-1141 AND ILE-1251.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-21. Tissue: Thalamus.
[6]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles." Gekeler V., Weger S., Probst H. Biochem. Biophys. Res. Commun. 169:796-802(1990) [PubMed: 1972623] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-215 AND 800-856.
[8]	"P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance." Kioka N., Tsubota J., Kakehi Y., Komano T., Gottesman M.M., Pastan I., Ueda K. Biochem. Biophys. Res. Commun. 162:224-231(1989) [PubMed: 2568832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-23.
[9]	"ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2." Kerb R., Hoffmeyer S., Brinkmann U. Pharmacogenomics 2:51-64(2001) [PubMed: 11258197] [Abstract] Cited for: REVIEW.
[10]	"An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene." Choi K.H., Chen C.-J., Kriegler M., Roninson I.B. Cell 53:519-529(1988) [PubMed: 2897240] [Abstract] Cited for: VARIANT VAL-185.
[11]	"Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors." Mickley L.A., Lee J.-S., Weng Z., Zhan Z., Alvarez M., Wilson W., Bates S.E., Fojo T. Blood 91:1749-1756(1998) [PubMed: 9473242] [Abstract] Cited for: VARIANTS ALA-893 AND THR-999.
[12]	"A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein." Decleves X., Chevillard S., Charpentier C., Vielh P., Laplanche J.-L. Hum. Mutat. 15:486-486(2000) [PubMed: 10790226] [Abstract] Cited for: VARIANT ASP-21.
[13]	"Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo." Hoffmeyer S., Burk O., von Richter O., Arnold H.P., Brockmoeller J., Johne A., Cascorbi I., Gerloff T., Roots I., Eichelbaum M., Brinkmann U. Proc. Natl. Acad. Sci. U.S.A. 97:3473-3478(2000) [PubMed: 10716719] [Abstract] Cited for: VARIANTS ASP-21; LEU-103 AND ASN-400.
[14]	"Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects." Cascorbi I., Gerloff T., Johne A., Meisel C., Hoffmeyer S., Schwab M., Schaeffeler E., Eichelbaum M., Brinkmann U., Roots I. Clin. Pharmacol. Ther. 69:169-174(2001) [PubMed: 11240981] [Abstract] Cited for: VARIANTS ASP-21; ASN-400; ALA-893; THR-893 AND PRO-1107.
[15]	"Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)." Honda T., Dan Y., Koyabu N., Ieiri I., Otsubo K., Higuchi S., Ohtani H., Sawada J. Drug Metab. Pharmacokinet. 17:479-481(2002) [PubMed: 15618700] [Abstract] Cited for: VARIANT LYS-108.
[16]	"Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone." Itoda M., Saito Y., Komamura K., Ueno K., Kamakura S., Ozawa S., Sawada J. Drug Metab. Pharmacokinet. 17:566-571(2002) [PubMed: 15618713] [Abstract] Cited for: VARIANT ILE-1251.
[17]	"Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population." Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y. J. Hum. Genet. 47:38-50(2002) [PubMed: 11829140] [Abstract] Cited for: VARIANTS ALA-893 AND THR-893.
[18]	"MDR1 Ala893 polymorphism is associated with inflammatory bowel disease." Brant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K., Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G., Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H. Am. J. Hum. Genet. 73:1282-1292(2003) [PubMed: 14610718] [Abstract] Cited for: VARIANTS ALA-893 AND THR-893, ASSOCIATION WITH SUSCEPTIBILITY TO IBD13.
[19]	Erratum Brant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K., Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G., Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H. Am. J. Hum. Genet. 74:1080-1080(2004)
[20]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-887.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

P-glycoprotein entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	M14758 mRNA. Translation: AAA59575.1. M29447 , M29424, M29425, M29426, M29427, M29428, M29429, M29430, M29431, M29432, M29433, M29434, M29435, M29436, M29437, M29438, M29439, M29440, M29441, M29442, M29443, M29444, M29445, M29446 Genomic DNA. Translation: AAA59576.1. AF016535 mRNA. Translation: AAB69423.1. AY910577 Genomic DNA. Translation: AAW82430.1. AK290159 mRNA. Translation: BAF82848.1. AC002457 Genomic DNA. Translation: AAM49149.1. Sequence problems. AC005068 Genomic DNA. No translation available. M37724 Genomic DNA. Translation: AAA88047.1. M37725 Genomic DNA. Translation: AAA88048.1. X58723 Genomic DNA. Translation: CAA41558.1.
IPI	IPI00027481.
PIR	DVHU1. A34914.
RefSeq	NP_000918.2.
UniGene	Hs.489033
3D structure databases
HSSP	HSSP built from PDB template 1MT0 based on UniProtKB P08716.
ModBase	Search...
Protein-protein interaction databases
IntAct	P08183. 2 interactions.
STRING	P08183.
Protein family/group databases
TCDB	3.A.1.201.1. ATP-binding cassette (ABC) superfamily.
PTM databases
PhosphoSite	P08183.
Proteomic databases
PRIDE	P08183.
Genome annotation databases
Ensembl	ENST00000265724; ENSP00000265724; ENSG00000085563; Homo sapiens. [Genome view] ENST00000394661; ENSP00000378156; ENSG00000085563; Homo sapiens. [Genome view] ENST00000415096; ENSP00000411075; ENSG00000085563; Homo sapiens. [Genome view] ENST00000416177; ENSP00000399419; ENSG00000085563; Homo sapiens. [Genome view]
GeneID	5243.
KEGG	hsa:5243.
Organism-specific databases
CTD	5243.
GeneCards	GC07M086970.
H-InvDB	HIX0033521. HIX0033618.
HGNC	HGNC:40. ABCB1.
HPA	CAB001716. HPA002199.
MIM	120080. phenotype. 171050. gene. 612244. phenotype.
PharmGKB	PA267.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P08183.
HOVERGEN	P08183.
Enzyme and pathway databases
BRENDA	3.6.3.44. 247.
Pathway_Interaction_DB	hif1_tfpathway. HIF-1-alpha transcription factor network.
Gene expression databases
ArrayExpress	P08183.
Bgee	P08183.
CleanEx	HS_ABCB1.
Genevestigator	P08183.
GermOnline	ENSG00000085563. Homo sapiens.
Family and domain databases
InterPro	IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
ProDom	PD000006. ABC_transporter. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00171. Adenosine triphosphate. DB00802. Alfentanil. DB01169. Arsenic trioxide. DB01072. Atazanavir. DB01136. Carvedilol. DB01394. Colchicine. DB00091. Cyclosporine. DB00694. Daunorubicin. DB00975. Dipyridamole. DB01196. Estramustine. DB00875. Flupenthixol. DB00619. Imatinib. DB01167. Itraconazole. DB00622. Nicardipine. DB01182. Propafenone. DB01103. Quinacrine. DB00908. Quinidine. DB00243. Ranolazine. DB01045. Rifampin. DB00778. Roxithromycin. DB01232. Saquinavir. DB00675. Tamoxifen. DB00570. Vinblastine.
NextBio	20254.
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Entry information

Entry name

MDR1_HUMAN

Accession

Primary (citable) accession number: P08183
Secondary accession number(s): A8K294, Q12755, Q14812

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	May 26, 2009
Last modified:	October 13, 2009
This is version 125 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.